Mane was substituted as Bayern Munich led Werder Bremen 4-1 at half time at the Allianz Arena on Tuesday night.Sadio Mane Will Miss World Cup 2022 Due to Injury
The 30-year-old only lasted 20 minutes before he was taken off the pitch for a suspected injury.
Mane was replaced by German international Leroy Sane, who went on to assist a goal for the Bavarians on the night
Senegal kick off their 2022 World Cup campaign in 13 days and will be hoping that their talisman was taken off for precautionary measure.
Bayern complete Bremen rout
The Bundesliga defending champions have extended their lead at the top of the table following a comfortable outing at the Arena.
Bayern proved to be no match for their visitors after a convincing 6-1 win sealed an eighth consecutive win in all competitions.
Serge Gnabry was the star of the night after he scored hat-trick, two of the goals were scored in a blistering first half display from the home side
Jamal Musiala opened the floodgates as early as the sixth minute but the goal only lasted four minutes before Bremen equalised through Anthony Jung.
However, the Bremen goal seemed to have annoyed the Bavarians, who went on rampage courtesy of two goals from Gnabry and Leon Goretzka.
The other scorer on the night for the Champions was 17-year-old Mathys Tel while Sane, who replaced Mane, picked up an assist, with Cameroonian star, Choupo-Moting missing a penalty